Abstract:Abstract: [Objective] To explore the clinical effect of unilateral biportal endoscopic (UBE) and posterior lumbar interbody fusion (PLIF) in the treatment of adjacent segment disease. Methods: From January 2021 to September 2022, 57 patients with adjacent segment disease were treated after lumbar fusion surgery. According to the results of preoperative doctor-patient communication, 31 cases were treated with UBE surgery and 26 cases were treated with PLIF. The perioperative period and related follow-up data of the two groups of patients were compared. Results: Both groups of patients successfully completed the operation. One case in each of the two groups suffered a tear of the nerve root epidural, and the postoperative pain in the lower limbs occurred. Hormones, dehydration and other symptomatic treatment were given. Smooth recovery after removing pillow and lying flat, extending the tube placement time and local pressurised suture treatment. UBE group in operation time [(84.1±11.5)min vs (149.2±11.4min, P<0.05], total incision length [(2.3±0.4)cm vs (12.3±1.5)cm, P<0.05], intraoperative blood loss Amount [(27.9±4.0)ml vs (266.5±16.0)ml, P<0.05], intraoperative fluoroscopy times [(3.1±0.5) times vs (5.4±0.5) times, P<0.05], time to go down to the ground [(2.5±0.5)d v S (3.6±0.6)d P<0.05], hospitalisation time [(5.4±0.6)d vs (9.6±0.6)d, P<0.05], full load activity time [(49.7±3.3)d vs (60.2±1.1)d, P<0 .05] All of them are significantly better than the PLIF group. The VAS and ODI scores of low back and leg pain in the two groups were significantly improved compared with preoperative (P<0.05). The area of the spinal canal and the vector diameter of the lateral crypt in the two groups of patients increased significantly compared with preoperative (P<0.05), and there was no significant change in the anterior convex angle of the lumbar vertebra in the two groups (P>0.05). During the last follow-up, the spinal area of the UBE group [(160.3±6.6)mm2 vs (179.9±1.8)mm2, P<0.05], lateral crypt arrow diameter [(3.9±.01)mm vs (4.2±0.1)mm, P<0.05]. It is significantly smaller than the PLIF group (P<0.05), and the comparison difference between the above indicators between the two groups before surgery is not statistically significant (P>0.05). Conclusion: Unilateral double-channel spinal endoscopy for the treatment of adjacent segment disease is safe and feasible, with little trauma, no destruction of the posterior tension band structure of the lumbar spine, fast recovery and good clinical effect.