Abstract:Abstract: Objective To explore the effects of three-dimensional balanced correct spine manipulation on pain and sagittal spinal pelvic parameters in patients with ankylosing spondylitis (AS). Methods A total of 102 AS patients admitted from January 2021 to June 2023 were randomly divided into 51 cases in the conventional group (conventional Western medicine treatment) and 51 cases in the correct spine group (conventional Western medicine treatment + three-dimensional balanced correct spine manipulation intervention) by drawing lot. The clinical, serum and imaging indexes of the two groups were compared. Results The 3-month efficacy, morning rigor time, VAS/BASDAI/BASFI score, TCM syndrome score, spinal function and Schober test in the correct spine group were better than those in the conventional group (P < 0.05). The levels of serum ESR, CRP and IL-6/17/23 in the correct spine group after 3 months of treatment were significantly lower than those in the conventional group (P < 0.05). After 3 months of treatment, SVA [(15.6±5.3) vs (25.4±8.0) mm], TK [(28.8±10.0) vs (35.7±11.2) °] and PT [(14.2±5.6) vs (17.0±6.7) °] in the correct spine group were significantly lower than those in the conventional group (P < 0.05). LL [(45.3±7.8) vs (39.8±8.2) °], PI [(45.6±6.7) vs (42.6±6.3) °] and SS [(33.5±7.0) vs (28.4±7.6) °] were significantly higher than those in the conventional group (P < 0.05). There was no statistically significance in toxic and side effects between the two groups (P > 0.05). Conclusions Three-dimensional balanced correct spine manipulation is safe and effective in the treatment of AS, which can significantly relieve pain, improve spinal function and sagittal spine pelvis related parameters. Key words: Ankylosing spondylitis; Three-dimensional balanced correct spine manipulation; Pain; Sagittal plane; Spinal pelvic parameters