Hippo信号通道在非创伤性股骨头坏死的作用△

Role of Hippo signal pathway in non- traumatic necrosis of femoral head

摘要:

Hippo 信号通道介导细胞内外信号传递，其调节细胞增殖、分化、凋亡进程，可在骨代谢、脂代谢及血管新生等方面发挥作用。故该通道可能对非创伤性股骨头坏死发病机制有重要意义。本文主要通过 Hippo 通道相关蛋白结构、功能在骨代谢、脂代谢及血管新生方面的作用机制进行探讨，寻找其在 NONFH 中的作用机制，从而为 NONFH 提供新的临床研究靶点。

Abstract:

Hippo signaling pathway mediates signal transmission inside and outside cells, which regulates the process of cell prolifera- tion, differentiation and apoptosis, and playes role in bone metabolism, lipid metabolism and angiogenesis. Therefore, this pathway may be of great significance in the pathogenesis of non-traumatic femoral head necrosis. This paper mainly discusses the mechanism of Hippo path- way related protein structure and function in bone metabolism and lipid metabolism, and looks for its mechanism in NONFH to provide a new clinical research target for NONFH.