Abstract:[Objective] To explore the significance of fascia iliaca compartment block (FICB) after total hip arthroplasty (THA) in the el- derly. [Methods] A total of140 elderly patients who underwent primary unilateral THA were randomly divided into 2 groups. Of them, 70 pa- tients were treated with high FICB combined with patient-controlled intravenous analgesia (PCIA) (the compound group), while the other 70 patients were treated with PCIA only (the PCIA group). Postoperative analgesia and clinical data were compared between the two groups. [Results] The compound group proved significantly superior to the PCIA group in terms of VAS score [(2.3±0.4) vs (2.6±0.7), P=0.002; (2.7±0.5) vs (3.4±0.7), P<0.001; (3.0±0.7) vs (3.4±0.6), P<0.001] and BCS scores [(3.3±0.5) vs (2.4±0.4), P<0.001; (2.5±0.4) vs (1.9±0.5) , P<0.001; (2.9±0.6) vs (2.1±0.6), P<0.001] 8, 12 and 24 hours postoperatively. In addition, the former was also significantly superior to the latter regard- ing to the total number of PCIA compressions within 48 hours [(5.2±2.2)times vs (9.8±1.4)times, P<0.001] and additional analgesic usage rate [5(7.1%) vs 18(25.7%), P=0.003] . Furthermore, the compound group was significantly superior to the PCIA group in terms of MMSE scores [(8.7±2.1) vs (11.2±1.9), P<0.001; (7.7±1.7) vs (8.7±1.8), P=0.001] and PSQI score [(8.7±2.1) vs (11.2±1.9), P<0.001; (7.7±1.7) vs (8.7±1.8), P=0.001] 1 and 3 days after surgery. Moreover, the compound group got significant higher Harris score at discharge (P<0.05) , with significantly lower complication rate, such as dizziness, nausea, vomiting and constipation within 5 days after operation than the PCIA group (P<0.05). [Conclusion] High FICB combined with PCIA does effectively alleviate pain, improve postoperative comfort, reduce the in- cidence of postoperative delirium and other complications, improve sleep quality, enhance the rapid recovery of hip function after THA in the elderly.