线粒体稳态在椎间盘退变中的作用△

Role of mitochondrial homeostasis in intervertebral disk degeneration

摘要:

椎间盘退变 （intervertebral disc degeneration, IDD） 作为临床上最常见的脊柱退行性疾病之一，是导致腰痛的主要病因，严重影响生活质量，并给家庭及社会带来巨大的经济负担。近年来，大量的研究发现，在退变的髓核细胞中能够观察到线粒体稳态系统的失调。线粒体稳态系统可调控髓核细胞的增殖与凋亡，进而影响 IDD 的病理生理过程。本文从线粒体抗氧化系统、线粒体蛋白质稳态、线粒体动力学、线粒体生物发生和线粒体自噬等方面，综述线粒体稳态系统在 IDD 发生发展过程中的调控作用，为探索 IDD 的早期防治提供新的思路。

Abstract:

Intervertebral disc degeneration (IDD), one of the most common clinical spinal degenerative diseases, is the main cause of low back pain, which could affect the quality of life of the population, and bring a huge economic burden to the family and society. In recent year, a large number of studies found that dysregulation of mitochondrial homeostatic system could be observed in degenerated nucleus pulposus cells. The mitochondrial homeostasis system can regulate the proliferation and apoptosis of nucleus pulposus cell, thereby affect- ing the pathophysiological process of IDD. This article reviews the regulatory roles of mitochondrial homeostasis in the development of IDD, involving mitochondrial antioxidant system, mitochondrial protein homeostasis, mitochondrial dynamics, mitochondrial biogenesis and mi- tophagy to provide new ideas for exploring the early prevention and treatment of IDD.