Abstract:[Objective] To explore the clinical outcomes of percutaneous retrograde pubic rami screw for fixation of fragile fracture of pelvis (FFP) in the elderly. [Methods] A retrospective study was conducted on 25 elderly patients (27 sides of pubic rami) who underwent percutaneous retrograde pubic rami screw for fixation of FFP in our hospital from June 2019 to December 2020. The clinical and imaging consequences were evaluated. [Results] All patients were operated smoothly without complications such as nerve and vascular injuries dur- ing the operation. All patients were followed up for (17.8±0.7) months, with the mean time to return to full weight-bearing activities of (7.8± 0.6) weeks. The Majeed scores significantly increased at the last follow-up compared with 3 months after surgery (P<0.05), whereas the hip internal-external rotation range of motion (ROM) and extension-flexion ROM remained unchanged (P>0.05). At the last follow-up, the clin- ical results were marked as excellent 19 sides, good 7 sides and fair 1 side with an excellent and good rate of 96.3% according to Majeed criteria. In terms of imaging, the reduction quality of fracture based on Matta criteria were excellent in 21 sides and good in 6 sides, with ex- cellent and good rate of 100.0%. Of them, 11 sides got fracture healing in 8 weeks, accounted for 40.7%, while the other 16 sides got heal- ing from 8 weeks to 12 weeks, accounted for 59.3%. There was no significant change in term of Tonnis classification for hip degeneration at the latest follow-up compared with those 3 months after surgery (P>0.05). [Conclusion] The percutaneous retrograde pubic rami screw has the advantages of less trauma, less blood loss, fewer complications and faster functional recovery for treatment of FFP in the elderly.