Abstract:[Objective] To investigate the efficiency of intermittent pneumatic compression (IPC) used for prevention of deep vein thrombosis (DVT) after Achilles tendon repair. [Methods] A total of 114 patients received minimally invasive surgical repair for acute Achilles tendon rupture in our hospital from January 2020 to January 2022. Based on postoperative doctor-patient communication, 59 pa- tients received postoperative routine plaster fixation (the conventional group), while the other 55 patients underwent postoperative routine plaster fixation combined with IPC treatment (IPC group). The incidence of postoperative complications and DVT was compared between the two groups. [Results] All patients in both groups were successfully operated on. Sural nerve injury was found in one case of the IPC group, whereas non in the conventional group, which was considered to be caused by intraoperative pulling and recovered after drug treat- ment, without a statistically significant difference between the two groups (P<0.05). Poor incision healing and superficial infection were not- ed in 3 patients in the conventional group, while 2 cases in the IPC group, which healed well after dressing change, with no statistically sig- nificant difference in incision healing grade between the two groups (P>0.05). Ultrasonographically, the incidence of DVT in the IPC group was significantly lower than that in the conventional group 2 weeks after surgery (5.5% vs 13.6%, P=0.042), whereas it became not signifi- cantly different between the two groups 4 weeks after surgery (20.0% vs 25.4%, P=0.737). [Conclusion] The IPC treatment does effectively reduce the incidence of DVT, without significant impact on wound healing and sural nerve.