Abstract:[Objective] To explore the main causes and characteristics of limb deformity in high altitude area to provide data support for the formulation of feasible prevention and treatment strategies. [Methods] From May to December 2021, based on 7 rounds of medical service tour, 1 free medical checking and 1 screening, involving personal interview, questionnaire survey and on-site physical examination, the data regarding various physical disabilities and limb deformities in Litang County, Sichuan Province, were collected and analyzed pri- marily to present the characteristics of the limb deformities. [Results] Among the 530 persons who were investigated in this study, 364 cas- es were found disabled extremity with limb deformity, accounting for 68.7%. Of them, 29 (8.5%) were of congenital deformity, 15 (4.4%) of post-traumatic deformity, 253 (74.0%) of degenerative deformity, 45 (13.1%) neurological sequelae deformity, and 22 (6.0%) other malfor- mations. Among all persons who had deformities, 363 were Tibetan and 1 was Han. The incidence of lower extremity deformity was higher than that of upper extremity, and knee was the most common deformity site, with an incidence of 49.8% (264/530). Knee deformities were mostly osteoarthritis, with bilateral involvement and severe severity, most of which had not been treated surgically. [Conclusion] The inci- dence of limb deformity is high in Litang County, mainly affected the Tibetan nationality. The causes of deformity are osteoarthritis, sequel- ae of neurological disorders and congenital limb deformity, etc., which may be related to the high altitude and hypoxia environment, the working methods of herdsmen in Tibetan areas and the limited local medical conditions, etc., which should be paid attention to.