NF-κB信号通道在膝骨关节炎的作用

Role of NF-κB signal pathway in knee osteoarthritis

摘要:

膝骨关节炎是中老年人常见的骨科疾病。而免疫炎症导致的关节损伤在其发病中有着重要作用，所以控制炎症反应对膝骨性关节炎预防和治疗具有重要的意义。炎性信号通路通过激活或抑制表达对膝骨关节炎（knee osteoarthritis, KOA）起到防治作用，核转录因子 κB（nuclear factor-kappa B, NF-κB）通道作为其中重要的炎性信号通路，可以通过调控靶基因的表达来改善膝关节炎性反应，从而达到预防和治疗 KOA 的作用。本文对 NF-κB 信号通道通过影响导致膝关节损伤的因素如软骨代谢平衡、膝关节滑膜组织炎等对 KOA 的作用进行综述，通过影响炎性因子、Toll 样受体和基质金属蛋白酶等上下游因子改善软骨滑膜病变，为临床医师提供一定参考。

Abstract:

Knee osteoarthritis (KOA) is a common orthopedic disease in the middle-aged and elderly. The joint damage caused by im- mune inflammation plays an important role in its pathogenesis, so modifying inflammatory reaction is of great significance for the prevention and treatment of knee osteoarthritis. Activating or inhibiting expression of inflammatory signaling pathways might be potential approaches for prevention and treatment of KOA. Among them, the NF-κB, an important inflammatory signaling pathway, can improve the inflammatory re- sponse of knee joint by regulating the expression of target gene, thus achieving the role of preventing and treating KOA. In this paper, the ef- fects of the NF-κB signal pathway on KOA by influencing cartilage metabolic balance and synovitis are reviewed. By regulating the up- stream and downstream factors such as inflammatory factors, Toll-like receptors and matrix metalloproteinases, the pathology of cartilage and synovium might be improved, thus this paper aims to provide some reference for clinicians.