骨关节炎氧化应激及其干预措施的研究进展

Research progress on the role of oxidative stress and related interventions in osteoarthritis

摘要:

骨关节炎 （osteoarthritis, OA） 是一种常见的慢性、高致畸性、退行性疾病，给全球医疗体系带来了巨大的经济负担。其中，氧化应激的激活及活性氧的过剩在骨关节炎的发生中具有重要作用，也是骨关节炎治疗的重要靶点。本文就骨性关节炎中氧化应激与活性氧的病理生理机制及其相关干预治疗措施的研究进展进行综述，为后续进一步研究提供参考。

Abstract:

Osteoarthritis is a common group of chronic, high-teratogenic, and degenerative arthritis, which brings an economic burden on global healthcare systems. Activation of oxidative stress and excess of reactive oxygen species play an important role in the occurrence of osteoarthritis and are also important targets for the treatment of osteoarthritis. This paper reviews the pathophysiological mechanism of oxi- dative stress and reactive oxygen species as well as the research progress of related therapeutic interventions, for the sake of providing a ref- erence for further research.