Abstract:[Objective] To compare the clinical efficacy of lower extremity axial distractor (LEAD) versus conventional traction table (CTT) assisted fracture reduction and intramedullary nailing in the treatment of Seinsheimer type Ⅴ femoral subtrochanteric fractures. [Methods] A retrospective study was performed on 49 patients who received fracture reduction and intramedullary nailing for Seinsheimer type Ⅴ femoral subtrochanteric fracture in our hospital from May 2012 to May 2021. According to preoperative doctor-patient communica- tion, LEAD reduction was used in 29 patients, while CTT reduction used in the remaining 20 patients. The perioperative period, follow-up and imaging data of the two groups were compared. [Results] The LEAD group proved significantly superior to the CTT group in terms of traction device installation time [(4.0±1.1) min vs (14.0±3.6) min, P<0.05], operation time [(134.4±33.3) min vs (196.6±103.0) min, P< 0.05], intraoperative blood loss [(231.0±109.7) ml vs (380.0±247.3) ml, P<0.05], intraoperative fluoroscopy [(28.5±4.7) times vs (31.8±4.0) times, P<0.05], nevertheless there were no significant differences in the total incision length, guide needle positioning times, closed-open reduction rate, incision healing grade, hospital stay, and walking time between the two groups (P>0.05). All of them were followed up for (15.4±2.5) months on a mean, and there was no significant difference in the time to resume full weight-bearing activities between the two groups (P<0.05). Compared with those 1 month after surgery, the Harris score, hip flexion-extension range of motion (ROM), and hip inter- nal-external rotation ROM significantly increased in both groups at the last follow-up (P<0.05), which proved not significantly different be- tween the two groups at any time points accordingly (P>0.05). In terms of imaging, there were no significant differences in the quality of fracture reduction or the imaging fracture healing time between the two groups (P>0.05). [Conclusion] Compared with conventional traction table, the lower extremity axial distractor does shorten operation time, reduce intraoperative blood loss and reduce intraoperative fluorosco- py times considerably for intramedullary nailing Seinsheimer type Ⅴ femoral subtrochanteric fractures.