Abstract:[Objective] To compare the clinical outcomes of the elastic stable intramedullary nail (ESIN) for fixation of length unstable tibial shaft fractures versus stable counterparts in children. [Methods] A retrospective study was conducted on 84 children who received ESIN for tibial shaft fractures in our hospital from January 2016 to November 2021. Among them, 32 children suffered from unstable frac- ture, while the remaining 52 children were of stable fracture. The perioperative, follow-up and imaging data were compared between the two groups. [Results] Although there were no significant differences in operation time, total incision length, intraoperative blood loss, inci- sion healing and hospital stay between the two groups (P<0.05), the unstable group had significantly more intraoperative fluoroscopy than the stable group [(12.4±1.5) times vs (10.3±1.7) times, P<0.05]. All patients in both groups were followed up for (13.3±2.3) months on a mean, and there was no a significant difference in the time to return full weight-bearing activity between the two groups (P>0.05). The AO- FAS scores and ankle dorsal extension- plantar flexion ROM significantly increased in both groups over time postoperatively (P<0.05), which proved not statistically significant between the two groups at any time points accordingly (P>0.05). In addition, there was no a signifi- cant difference in Johner-Wruh scale between the two groups at the latest follow-up (P>0.05), with normal gait and squat activity in all chil- dren in both groups. Radiographically, there were significant improvements in tibial alignment, leg length discrepancy (LLD) and tibial an- gulation in both groups postoperatively compared with those preoperatively (P<0.05). The unstable group proved significantly inferior to the stable group in terms of tibial alignment [excellent/good/poor, (9/18/5) vs (33/18/1), P<0.05], and LLD [(2.1±2.2) mm vs (0.7±1.3) mm, P< 0.05], despite that there was no statistical significance in tibia angulation between the two groups immediately postoperatively (P>0.05).However, all differences in the above indexes became not statistically significant between the two groups at the latest follow-up (P>0.05). There was no significant difference in fracture healing time on images between the two groups (P>0.05). [Conclusion] ESIN, a safe and ef- fective for the length stable tibial shaft fractures in school-age children, is also suitable for the length unstable fractures. Although there is a greater possibility of postoperative shortening in length unstable fractures, the overgrowth can compensate for the final difference in lower limb length.