富血小板血浆治疗骨折的研究进展

Research progress in platelet-rich plasma used for treatment of fracture

摘要:

富血小板血浆 （platelet-rich plasma, PRP） 是通过离心、血细胞单采等方式从动物或人全血中提取的富含高浓度血小板的血浆，由于来源于自体血液不产生免疫排斥，是目前应用前景优良的再生医学治疗药物之一，其临床治疗价值与干细胞相当。自 Anitua 于 1999 年发现 PRP 能显著促进骨组织修复以来，PRP 由于其自身优良的性能，在骨科疾患中得到广泛应用。 本文将分别从 PRP 影响骨愈合作用机制、促进骨愈合应用及研究进展、展望等方面综述应用 PRP 治疗骨折的研究进展。

Abstract:

Platelet-rich plasma (PRP) is a product of plasma with high-concentration of platelet extracted from animal or human whole blood by centrifugation or single collection of blood cells, and proves one of the promising drugs for regenerative medicine at present with clinical therapeutic value equivalent to the stem cells. Since Anitua discovered that PRP significantly promoted bone tissue repair in 1999, PRP has been widely used in orthopedic diseases because of its excellent properties. This article reviewed the research progress of PRP in the treatment of fracture in terms of the mechanism of PRP affecting bone biology and promoting bone healing.