Abstract:[Objective] To analyze the learning curve of robotic knee systemassisted total knee arthroplasty (TKA). [Methods] From September 2021 to September 2022, 17 patients with knee arthritis underwent robotic knee systemassisted TKA surgery in our hospital. The learning curve was analyzed through the cumulative summation (CUSUM) method. The baseline characteristics, operation conditions, and postoperative outcomes at different stages of the learning curve were compared. [Results] The operation time showed a downward trend with the increase of the number of operations, and the inflection point of the learning curve was around the 10th operation. Based on the sequence, the patients were divided into the learning group and the mature group. There was no statistically significant difference in age, gender compo- sition and course of disease between the two groups (P>0.05). The mature group proved significantly superior to the learning group in terms of operation time [(123.3±11.3) min vs (147.3±11.3) min, P<0.05], the positioning time of the robot knee system [(15.9±2.1) min vs (22.2±6.1) min, P<0.05], the prosthetic planning time [(17.6±4.2) min vs (23.5±5.2) min, P<0.05], nevertheless, there were no significant differences in femoral registration time, tibial registration time, distal femoral osteotomy time, proximal tibial osteotomy time, femoral four-in-one osteoto- my time, intraoperative blood loss, postoperative HKA, incision healing, and hospital stay between the two groups (P>0.05). In addition, there were no significant differences in KSS clinical score, KSS functional score and HSS score between the two groups 1 month after surgery (P>0.05). [Conclusion] The learning curve of robotic knee system-assisted TKA surgery is around 10 operations.