Abstract:[Objective] To evaluate the clinical outcomes of local injection of platelet rich plasma lysate combined oral Jiegu pill for tib- iofibular fracture nonunion. [Methods] From January 2019 to January 2022, a total of 46 patients received local injection for tibiofibular frac- ture nonunion. According to doctor-patient communication, 23 patients were treated with local injection of platelet-rich plasma lysate com- bined with oral Jiegu pills (the combined group), while other 23 patients underwent local injection of platelet- rich plasma lysate only (the mere group). The clinical and imaging data were compared between the two groups. [Results] All patients in both groups received treatment successfully without serious adverse reactions. There was no significant difference in VAS score for therapy compliance between the two groups (P>0.05). By 6 months after treatment, 23 cases (100%) in the combined group, while 21 cases (91.3%) in the mere group achieved clinical healing, and the clinical healing time in the combined group was significantly earlier than that in the mere group [(3.2±0.5) months vs (4.1±0.7) months, P<0.001]. The VAS scores of local tenderness in both groups decreased significantly over time (P<0.05), and the com- bined group had significantly lower local tenderness VAS score than the mere group 2 month after treatment [(4.1±0.2) vs (5.1±0.2), P< 0.001]. Radiographically, the image scores increased significantly over time in both groups (P<0.05). Although there was no significant differ- ence in image scores between the two groups before treatment (P>0.05), the combined group proved significantly superior to the mere group 2 months after treatment [(2.5±0.4) vs (1.9±0.4), P<0.001]. [Conclusion] The local injection and platelet-rich plasma lysate combined with oral Jiegu pill is a less traumatic and effective therapy for tibiofibular fracture nonunion.