富血小板血浆裂解液联合接骨丸治疗胫腓不连接
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张中禹,主治医师,研究方向:四肢创伤,(电话)13506303319,(电子信箱)187320071@qq.com

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R681.57

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第三批威海市重点专科项目(创伤科)


Platelet rich plasma lysate and Jiegu pill for tibiofibular fracture nonunion
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    摘要:

    [目的] 评价富血小板血浆裂解液联合接骨丸治疗胫腓不连接的临床疗效。[方法] 2019 年 1 月—2022 年 1 月,对 46 例胫腓骨不连接患者局部注射治疗。依据医患沟通结果,23 例采用富血小板血浆裂解液联合接骨药丸治疗(联合组),另外 23 例采用富血小板血浆裂解液治疗(单一组)。比较两组临床与影像资料。[结果]两组所有患者均顺利接受治疗,无严重不良反应。两组治疗顺应性 VAS 评分的差异无统计学意义 (P>0.05)。至治疗后 6 个月,联合组 23 例 (100%),单一组 21 例 (91.3%)达到临床愈合,联合组临床愈合时间显著早于单一组 [(3.2±0.5) 个月 vs (4.1±0.7) 个月, P<0.001]。随时间推移,两组患者局部压痛 VAS 评分均显著下降(P<0.05);治疗后 2 个月,联合组局部压痛 VAS 评分显著低于单一组 [(4.1±0.2) vs (5.1±0.2), P< 0.001]。影像方面,随时间推移,两组影像评分均显著增加(P<0.05),治疗前两组间影像评分的差异无统计学意义(P>0.05),治疗后 2 个月,联合组影像学评分显著高于单一组 [(2.5±0.4) vs (1.9±0.4), P<0.001]。[结论]富血小板血浆裂解液联合接骨丸治疗胫腓不连接,创伤小,疗效确切。

    Abstract:

    [Objective] To evaluate the clinical outcomes of local injection of platelet rich plasma lysate combined oral Jiegu pill for tib- iofibular fracture nonunion. [Methods] From January 2019 to January 2022, a total of 46 patients received local injection for tibiofibular frac- ture nonunion. According to doctor-patient communication, 23 patients were treated with local injection of platelet-rich plasma lysate com- bined with oral Jiegu pills (the combined group), while other 23 patients underwent local injection of platelet- rich plasma lysate only (the mere group). The clinical and imaging data were compared between the two groups. [Results] All patients in both groups received treatment successfully without serious adverse reactions. There was no significant difference in VAS score for therapy compliance between the two groups (P>0.05). By 6 months after treatment, 23 cases (100%) in the combined group, while 21 cases (91.3%) in the mere group achieved clinical healing, and the clinical healing time in the combined group was significantly earlier than that in the mere group [(3.2±0.5) months vs (4.1±0.7) months, P<0.001]. The VAS scores of local tenderness in both groups decreased significantly over time (P<0.05), and the com- bined group had significantly lower local tenderness VAS score than the mere group 2 month after treatment [(4.1±0.2) vs (5.1±0.2), P< 0.001]. Radiographically, the image scores increased significantly over time in both groups (P<0.05). Although there was no significant differ- ence in image scores between the two groups before treatment (P>0.05), the combined group proved significantly superior to the mere group 2 months after treatment [(2.5±0.4) vs (1.9±0.4), P<0.001]. [Conclusion] The local injection and platelet-rich plasma lysate combined with oral Jiegu pill is a less traumatic and effective therapy for tibiofibular fracture nonunion.

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张中禹,于丽,林治建,等. 富血小板血浆裂解液联合接骨丸治疗胫腓不连接[J]. 中国矫形外科杂志, 2023, 31 (17): 1625-1629. DOI:10.3977/j. issn.1005-8478.2023.17.18.
ZHANG Zhong-yu, YU Li, LIN Zhi-jian, et al. Platelet rich plasma lysate and Jiegu pill for tibiofibular fracture nonunion[J]. Orthopedic Journal of China , 2023, 31 (17): 1625-1629. DOI:10.3977/j. issn.1005-8478.2023.17.18.

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  • 收稿日期:2023-05-30
  • 最后修改日期:2023-06-21
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  • 在线发布日期: 2025-08-05
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