骨骼疾病巨噬细胞与破骨细胞交互作用的研究进展△

Research progress on interaction between macrophages and osteoclasts

摘要:

骨免疫学认为巨噬细胞和破骨细胞之间的相互作用可以调控骨骼疾病，巨噬细胞-破骨细胞轴在骨免疫中发挥重要作用。人工关节产生的磨损颗粒刺激破骨细胞发生骨溶解，巨噬细胞吞噬磨损颗粒产生慢性炎症导致无菌性松动的发生。而巨噬细胞通过抗炎作用和促进破骨细胞分化促使骨折愈合。破骨细胞活跃是骨质疏松发生的主要原因，巨噬细胞在其中扮演重要的角色。同时巨噬细胞被认为是类风湿性关节炎患者破骨细胞过度活跃的重要原因。本文就骨免疫中巨噬细胞和破骨细胞的相互作用在相关骨骼疾病中的作用进行综述。

Abstract:

Osteoimmunology demonstrates that the interaction between macrophages and osteoclasts is involved in regulating bone state, in other word, the macrophage-osteoclast axis plays an important role in bone immunity. The wear particles produced by prosthesis stimulate osteoclasts to dissolve bone, while macrophages devours wear particles to produce chronic inflammation, leading to aseptic loosen- ing. Macrophages promote fracture healing through anti-inflammatory effect and osteoclast differentiation. However, osteoclast activity is the main cause of osteoporosis, in which macrophages play an important role. Macrophages are also considered to be an important cause of exces- sive osteoclast activity in patients with rheumatoid arthritis. This paper reviews the role of the interaction between macrophages and osteo- clasts in bone immunity in related bone disorders.