Abstract: [Objective] To investigate the clinical effect of enhanced recovery after surgery (ERAS) nursing in perioperative period of re- section of intraspinal tumor. [Methods] From March 2020 to October 2022, a total of 48 patients who underwent surgical resection of intra- spinal tumors in our hospital were randomly divided into two groups. Of them, 24 patients received perioperative ERAS nursing, while the other 24 patients received perioperative routine nursing. The early postoperative clinical data of the two groups were compared. [Results] All patients in both groups were successfully operated on, without death, nerve injury and other serious complications. Incision pain VAS scores in both groups were significantly decreased over time (P＜0.05). The ERAS group proved significantly lower VAS scores for incision pain than the routine group at 12 hours (h), 24 h, 48 h and 72 h postoperatively [(2.7±0.6) vs (5.2±1.2), P＜0.001; (2.9±0.4) vs (4.4±1.3), P＜0.001; (2.3±0.5) vs (3.3±1.0), P＜0.001; (1.6±0.4) vs (2.1±0.3), P＜0.001]. In addition, the ERAS group resumed ambulation postoperatively signifi- cantly earlier than the routine group [(1.4±0.5) days vs (3.0±1.2) days, P＜0.001], moreover, the former proved significantly shorter postopera- tive hospital stay than the routine group [(6.5±1.5) days vs (10.3±2.1) days, P＜0.001], furthermore, the ERAS group had significantly lower overall postoperative complication rate than the routine group (8.3% vs 29.2%, P=0.036). [Conclusion] The enhanced recovery after surgery (ERAS) nursing is safe and effective for perioperative period of resection of intraspinal tumor, and does effectively relieve postoperative pain and reduce the occurrence of postoperative complications.