锂生物材料在骨缺损修复的研究进展△

Advances in the study of lithium biomaterials for bone defect repair

摘要:

骨缺损的修复一直是临床上亟待解决的问题，目前临床应用较多的骨修复材料有异体骨、自体骨、人工骨等。异体骨植入人体后可产生免疫排斥反应和移植物抗宿主反应；人工骨价格昂贵、成骨作用弱；自体骨来源比较局限，取骨也会给患者造成额外损伤；上述材料的缺点均影响了骨修复材料在临床上的应用。近年来，锂及相关生物材料因良好的生物相容性和成骨作用而在骨修复领域受到广泛关注，现就锂元素及其相关生物医学材料如水凝胶、生物支架、纳米涂层等在骨缺损修复中的作用和作用机制进行综述，以期为研究修复骨缺损提供新的视野。

Abstract:

The repair of bone defects has always been an important problem to be solved in clinic. At present, the bone repair materi- als used in clinical practice include allogeneic bone, autogenous bone, artificial bone and so on. The bone allograft has risk of immunologi- cal rejection and graft-versus-host reaction, while the artificial bone is expensive and has weak osteogenic effect, the bone autograft is limit- ed in source with morbidity of the donor site. All the shortcomings of the abovementioned materials impacted their application for bone re- pair in clinical setting. In recent years, lithium and related biomaterials have attracted wide attention in the field of bone repair due to their good biocompatibility and osteogenic potential. This article reviews the role and mechanism of lithium and related biomedical materials such as hydrogels, biological scaffolds and nano-coatings used in repairing bone defects, in order to provide a new vision for the study of bone repair.