Abstract:[Objective] To introduce the surgical technique and preliminary results of osteochondral autografting combined with plate- let-rich plasma in the treatment of talus cartilage defect. [Methods] A total of 8 patients received the abovementioned surgical treatment for talus cartilage defect. Preoperative osteochondral autograft transplantation plan was developed. The worn cartilage surface of the talus was exposed and debrided through the anterolateral approach. Based on the aera of cartilage defect, 1 to 3 circular bone slots were made on the recipient site. Osteochondral grafts, which harvested from the non-weight-bearing cartilage surface of the lateral femoral condyle con- sistent with the shape and size of the recipient bone slots, were packed into the bone slots in the talus cartilage defect aera to keep smooth with the articular surface, and then the incision was closed in layers. Finally, platelet rich plasma (PRP) prepared with autogenous blood was injected into the affected joint. [Result] All the 8 patients had operation performed successfully without serious complications, and fol- lowed up for (24.5±4.4) months in a mean. Compared with those preoperatively, the pain VAS score significantly decreased [(7.3±1.0), (1.0± 0.3), P＜0.05]. AOFAS ankle and hindfoot score increased significantly at the latest follow-up [(43.3±4.4), (87.6±5.7), P＜0.05]. The salvage rate of the ankle was 100% 24 months after surgery. [Results] The osteochondral autograft transplantation combined with platelet-rich plas- ma for the treatment of talus cartilage defect is feasible and does achieve satisfactory clinical consequences.