椎管内痛风的研究现状

Current research on intraspinal gout

摘要:

痛风是指单钠尿酸盐 （monosodium urate, MSU） 结晶超过了其在血液或者组织液的饱和度，从而沉积在全身关节， 能够诱发局部炎症反应和组织结构破坏的代谢性疾病。当 MSU 沉积在关节突关节、黄韧带、硬膜外间隙等部位时，便可能导致脊柱椎管内痛风的形成。该病可发生于颈椎、胸椎、腰椎各个节段，早期无特异性临床症状，常规的影像学检查手段不易诊断该病，因此容易发生误诊误治。自 1950 年首次报道该病以来，已经有多篇文献分别从该病的病因、临床表现、诊断和治疗等方面进行了讨论。本文将在此基础上，对上述文献进行综述，以便加深对该病的认识。

Abstract:

Gout refers to a metabolic disease in which monosodium urate (MSU) crystals exceed their saturation in blood or interstitial fluid, thereby depositing in joints throughout the body, which can induce local inflammatory responses and tissue structure destruction. When MSU is deposited in the facet joint, ligament flavum, epidural space, etc., it may lead to the formation of gout in the spinal canal. This disease can occur in various segments, involving cervical, thoracic and lumbar spine, with no specific clinical symptoms in the early stage and lack of conventional imaging features, therefore is very prone to misdiagnosis and mistreatment. Since the disease was first reported in 1950, several publications have summarized the pathogenesis, clinical manifestations, diagnosis and treatment of the disease. On this basis, a literature review was conducted in order to deepen the understanding of the disease.