兰州市中老年体质与骨质疏松调查△

An investigation on physical condition and osteoporosis in the middle age and elderly in Lanzhou city

摘要:

[目的]探讨中老年人年龄、性别和体质指数（body mass index, BMI）与骨质疏松症（osteoporosis, OP）之间关系。[方法]兰州本地居民 958 人纳入本研究，获取观察对象的体质资料，检测骨密度，并依据诊断标准确定是否 OP。对此人群的资料进行描述性分析，以是否 OP 的二分变量为因变量，其他因素为自变量，行多因素逻辑回归分析，探索 OP 发生的相关因素。[结果]本组男 457 人，女 501 人；年龄 40~89 岁，平均（61.7±7.5）岁；男性 OP 检出率为 2.7%~21.5%，女性 OP 检出率 11.9%~61.0%。随年龄增加，男性和女性的 BMI 均呈下降趋势，但差异均无统计学意义（P＞0.05）；随年龄增加，男性和女性的 OP 检出率均显著上升（P＜ 0.001）。相同年龄组，男性 BMI 大于女性，但差异均无统计学意义（P＞0.05）；但是，相同年龄组男性 OP 的检出率均显著低于女性 （P＜0.001）。逻辑回归表明：女性（OR=3.782, 95%CI 2.415~5.85, P＜0.001）， 高龄（OR=2.031, 95%CI 1.724~2.831, P＜0.001）是 OP 发生的独立危险因素，而大 BMI（OR=0.447, 95%CI 0.361~0.693, P＜0.001）是 OP 发生的保护因素。[结论]此组人群随年龄增加 OP 的发生率显著增加，女性 OP 的发生率显著高于男性。在此人群中，高 BMI 是 OP 发生的保护性因素。

Abstract:

[Objective] To investigate the relationship between age, sex, body mass index (BMI) and osteoporosis (OP) in middle-aged and elderly people. [Methods] A total of 958 local residents in Lanzhou city were included in this study. The data regarding to the physical condition of the subjects were obtained, bone mineral density (BMD) was detected, based on which whether or not OP was determined accord- ing to diagnostic criteria. Descriptive analysis was performed on the data of this population, and multi-factor logistic regression analysis was performed to explore the related factors of OP occurrence with binary variable of OP or not as the dependent variable and other factors as the independent variables. [Results] There were 457 males and 501 females in this population, aged from 40 to 89 years old with a mean (61.7± 7.5) years old. OP was detected from 2.7% to 21.5% in the male, while from 11.9% to 61.0% in the female. The BMI of both men and women decreased with age, but the differences were not statistically significant (P＞0.05). The OP detection rates increased significantly with age in both males and females (P＞0.001). The males had greater BMI than the female in the all age groups, but the differences were not statistically significant (P＞0.05). However, the detection rate of OP in males was significantly lower than that in females in all age groups (P＜0.001). As results of logistic regression, the females (OR=3.782, 95%CI 2.415~5.85, P＜0.001) and advanced age (OR=2.031, 95%CI 1.724~2.831, P＜ 0.001) were independent risk factor for OP, while greater BMI (OR=0.447, 95%CI 0.361~0.693, P＜0.001) was a protective factor for the oc- currence of OP. [Conclusion] The incidence of OP in this population increases remarkably with age, and is significantly higher in females than in males. In addition, greater BMI is a protective factor for the occurrence of OP in this population.