Abstract:[Objective] To compare the clinical efficacy of Ganz approach versus Kocher-Langenbeck (K-L) approach for open reduc-tion and internal fixation (ORIF) of Pipkin type I and II femoral head fractures. [Methods] A retrospective study was conducted on 24 pa-tients who receive ORIF of femoral head fractures in our hospital from April 2017 to February 2022. According to the results of doctor-pa-tient communication, 12 patients had ORIF performed through the Ganz approach, while the other 12 patients were through K-L approach.The clinical and imaging documents of the two groups were compared. [Results] All patients in both groups were successfully operated on.The Ganz group proved significantly superior to the K-L group in terms of operative time [(94.6±15.1) min vs (109.2±14.6) min, P=0.025]and intraoperative blood loss [(254.2±78.2) ml vs (316.7±65.1) ml, P=0.045], despite of insignificant differences in incision length and inci-sion healing grade between the two groups (P>0.05). As time went during follow-up period lasted for (17.1±8.4) months in a mean, the visu-al analogue scale (VAS) for pain and Harris score of the two groups were significantly increased (P<0.05). The Ganz group was significantlybetter than the K-L group regarding Harris score one month after surgery [(44.1±2.5) vs (40.2±3.0), P=0.002], regardless of the fact thatthere were no significant differences in VAS score, and Harris score at other corresponding time points between the two groups (P>0.05).Radiographically, there was no significant difference in fracture reduction quality between the two groups (P>0.05). At the last follow-up,there were no significant differences in Brooker grade, Ficat stage and Tonnis grade between the two groups (P>0.05). [Conclusion] TheGanz approach has the advantages of shortening operation time, reducing intraoperative bleeding, and improving recovery of hip function af-ter operation over the K-L approach for femoral head fractures.