Abstract:[Objective] To compare the early clinical consequences of percutaneous endoscopic interlaminar discectomy (PEID) versusunilateral biportal endoscopy (UBE) for lumbar disc herniation. [Methods] A retrospective study was done on 60 patients who underwentendoscopic discectomy for lumbar disc herniation from June 2016 to December 2022. According to the technology developed in different pe-riods, 30 patients underwent PEID and 30 patients underwent UBE. The perioperative and follow-up results were compared between thetwo groups. Clinical outcomes were assessed by the visual analogue scale (VAS), Oswestry disability index (ODI) score, and modifiedMacnab criteria at different follow-up times. [Results] All patients were successfully operated, with no complications of severe nerve injuryduring the operation. The PEID group proved significantly superior to UBE group in terms of operation time [(42.4±14.2) min vs (118.5±23.8) min, P<0.001], incision length [(1.1±0.2) cm vs (2.4±0.3) cm, P<0.001], intraoperative blood loss [(16.2±11.0) ml vs (39.8± 6.5) ml, P<0.001], intraoperative fluoroscopy times [(3.8±0.9) times vs (7.2±2.0) times, P<0.001], postoperative walking time [(1.2±0.3) days vs (2.3±0.6) days, P<0.001] and hospital stay [(4.8±0.3) days vs (6.2±2.1) days, P=0.016]. In addition, the PEID was also significantly superior tothe UBE group in VAS score for pain 3 days after surgery [(1.8±0.8) vs (2.4±1.1), P=0.021]. The VAS scores for lower back and leg pain, aswell as ODI score significantly decreased in both groups over time (P<0.05), whereas which were not significant between the two groups at 1month, 6 months postoperatively and the latest follow-up (P>0.05). According to the modified Macnab's criteria, the excellent and good rateof clinical outcome was 90.0% in the PEID group, whereas 86.6% in the UBE group, which was not statistically significant between the twogroups (P>0.05). [Conclusion] The PEID takes an advantage of less surgical trauma, while the UBE has a benefit of wider field of view to fa-cilitate fine operation under the endoscope.