Abstract:[Objective] To explore the significance of computer aided design (CAD)/rapid prototyping (RP) personalized guide in percu-taneous transforaminal endoscopic discectomy (PTED) for lumbar disc herniation (LDH). [Methods] From October 2021 to September 2022,a total of 80 patients who were undergoing PTED in our hospital were randomly divided into two groups. Of them, 40 patients received person-alized guide aided PTED, while other 40 patients received conventional PTED. The clinical and imaging data of the two groups were com-pared. [Results] The guide group proved significantly superior to the conventional group in terms of operation time [(53.3±8.8) min vs (74.8±13.4) min, P<0.05], intraoperative fluoroscopy times [(2.9±0.7) times vs (8.3±2.6) times, P<0.05], puncture times [(1.9±0.7) times vs (4.5±1.3) times, P<0.05], postoperative ambulation time [(1.4±0.2) days vs (2.6±0.5) days, P<0.05]. The VAS and RMDQ scores significantly re-duced in both groups over time (P<0.05). Although there were not statistically significant difference in above 2 scores between the two groupsbefore surgery (P>0.05), the guide group was marked significantly lower than the conventional group 1 week postoperatively in terms of VASscore [(1.0±0.3) vs (1.9±0.5), P<0.05] and RMDQ [(2.2±0.8) vs (4.0±1.5), P<0.05], despite of the fact that the difference became not statisti-cally significant between the two groups 1 month after surgery (P>0.05). Regarding imaging, the canal occupancy rate significantly decreasedin both groups postoperatively compared with that preoperatively in both groups (P<0.05), whereas which was not significantly different be-tween the two groups at any time points accordingly. [Conclusion] The CAD/RP made personalized guide does improve the success rate ofpuncture, and has considerable advantages in short-term postoperative pain relief and lumbar function improvement.