Abstract:[Objective] To evaluate the application value of personalized puncture in percutaneous kyphoplasty (PKP) for osteoporoticvertebral fractures. [Methods] From January 2020 to January 2023, 162 patients with osteoporotic vertebral fractures of 276 vertebrae weretreated with personalized percutaneous kyphoplasty. The clinical effect was evaluated by VAS score and ODI scores, as well as the vertebralheight and local kyphotic Cobb Angle were measured on images. [Results] All patients were successfully operated on without serious com-plications. Although bone cement leakage occurred in 23 cases during the operation, including paravertebral leakage in 6 cases, interverte-bral leakage in 17 cases and no intraspinal leakage, no obvious clinical symptoms were presented in anyone of them. Compared with thosepreoperatively, the VAS scores [(8.6±0.8), (1.8±0.7), (1.7±0.9), P＜0.001] and ODI scores [(72.6±1.2), (28.4±2.3), (27.9±2.5), P＜0.001], aswell as anterior vertebral height [(15.4±1.3) mm, (19.3±2.5) mm, (18.9±2.9) mm, P＜0.001], middle vertebral body height [(17.2±1.4) mm,(21.3±3.1) mm, (20.8±3.4) mm, P＜0.001] and local kyphotic Cobb angle [(14.6±4.3)°, (9.4±3.8)°, (9.2±4.1)°, P＜0.001] significantly im-proved 1 day postoperatively and at the latest follow-up. [Conclusion] This individualized puncture in PKP is a safe and effective methodfor the treatment of osteoporotic vertebral fractures.