Abstract:[Objective] To explore the choice of surgical methods and the influence on prognosis of hyperextension tibial plateau frac- tures. [Methods] A retrospective study was done on 53 patients who received open reduction and internal fixation (ORIF) for tibial plateau fractures in our hospital from January 2016 to January 2021. According to Firoozabadi's criteria, 19 patients fall in hyperextension (HE) group, while other 34 patients were in the non-hyperextension (NHE) group. The documents regarding to perioperative period, follow-up and imaging were compared between the two groups. [Results] The HE group proved significantly greater than the NHE group in terms of overall incidence of combined injury (63.1% vs 23.4%, P<0.05), operation time [(141.3±19.7) min vs (107.6±15.4) min, P<0.05], incision length [(19.6±4.1) cm vs (15.4±3.4) cm, P<0.05] and intraoperative blood loss [(228.3±33.9) ml vs (163.4±24.1) ml, P<0.05], despite of in- significant differences in intraoperative fluoroscopy times, ambulation time, incision healing grade and hospital stay between the two groups (P>0.05). The mean follow-up time was of (14.3±1.1) months, and there was no significant difference in time to resume full weight-bearing activity between the two groups (P>0.05). Both KSS clinical score and KSS functional score were significantly increased in both groups over time (P<0.05), of which the KSS functional score in HE group was significantly lower than that of NHE group 2 months after surgery [(50.4± 5.4) vs (54.7±5.8), P<0.05]. Radiographically, the joint congruity significantly improved (P<0.05), while MPTA significantly increased post- operatively compared with those preoperatively (P<0.05). However, there were no significant differences in joint congruity, fracture healing time and MPTA between the two groups any time points accordingly (P>0.05). The PTS in HE group were significantly smaller than that in the NHE group preoperatively (P<0.05), while became not statistically significant between the two groups postoperatively (P>0.05). [Con- clusion] Hyperextension tibial plateau fracture is often associated with other structural injuries, and the surgical treatment is much more complicated with poor prognosis compared with the non-hyperextension counterpart.