Abstract:[Objective] To investigate the clinical outcomes of distraction by Ilizarov frame combined with selective tibial nerve constric- tion in the treatment of spastic talipes equinovarus. [Methods] A total of 37 patients (48 feet) with cerebral palsy spastic talipes equinovarus received limited soft tissue release, selective tibia nerve constriction followed by gradual distraction with Ilizarov frame in our hospital from January 2015 to December 2019, including 32 feet of Dimeglio grade III and 16 feet of grade IV. The clinical and imaging documents were evaluated. [Results] All patients had the operations performed successfully without neurovascular injury, with operation time of (96.9±14.2) min, intraoperative blood loss of (39.7±10.4) ml, partial loading time of (6.7±0.9) days, adjustment time of external fixator of (8.0±1.1) weeks, full loading activity time of (9.9±1.7) weeks and external fixator carrying time of (12.2±1.0) weeks. Compared with those preoperatively, the ICFSG [(37.8±4.0), (8.7±6.4), P<0.05] and MAS grade [3.0 (3.0~4.0), 1.0 (0~3.0), P<0.05] significantly reduced, while the dorsal extensionplantar flexion of the ankle [(12.4±6.9)°, (33.7±10.4)°, P<0.05] and AOFAS score [(42.1±7.7), (81.2±9.3), P<0.05] significantly increased at the latest follow up lasted for (18.3±3.6) months. Regarding to imaging, compared with those preoperatively, the TC [(8.9±3.4)°, (30.0±6.1)°, P<0.05], TF [(24.2±13.0)°, (2.6±6.7)°, P<0.05] and LTC [(5.0±2.4)°, (34.8±7.3)°, P<0.05] improved significantly at the latest follow-up. [Conclusion] The Ilizarov technique combined with selective tibial nerve constriction is effective and safe in the treatment of spastic talipes equinovarus caused by cerebral palsy.