Abstract:[Objective] To investigate the medium-term clinical efficacy of autologous fascia lata patch used to bridge unrepairable giant rotator cuff tear. [Methods] A retrospective study was done on 12 patients who underwent autologous fascia lata bridging for unrepairable giant rotator cuff tear from January 2017 to December 2019. According to the results of doctor-patient communication, 6 patients received open surgery (open group), while other 6 patients received arthroscopic fascia lata patch bridging (arthroscopic group). The clinical and imaging documents of the two groups were compared. [Results] All patients in both groups were successfully operated on. The open group proved significantly superior to the arthroscopic group in term of operation time [(120.0±6.6) min vs (174.1±7.3) min, P＜0.001], while the former was significantly inferior to the latter in terms of incision length [(16.5±1.0) cm vs (11.5±1.2) cm, P＜0.001] and intraoperative blood loss [(31.6±7.5) ml vs (14.1±4.9) ml, P＜0.001]. At the latest follow-up lasted for (43.1±6.4) months in an average, the VAS, ASES and Constant-Murley scores were significantly improved compared with those before surgery in both groups (P＜0.05), however, there were no significant differences in the above items between the two groups at any corresponding time points (P＞0.05). Regarding imaging, the subacromial space (SAS) was significantly increased postoperatively in both groups compared with that before operation (P＜0.05), whereas there was no significant difference in SAS between the two groups at any time points accordingly (P＞0.05). MRI showed that the fascia lata patch healed well with the supraspinatus tendon stump and the greater tubercle of humerus. [Conclusion] Fascia lata patch bridging for huge unrepairable rotator cuff tear has good medium-term efficacy, and there is no significant difference between the open surgery and the arthroscopic counterpart.