激素性股骨头坏死发病机制的研究进展△

Research progress on pathogenesis of steroid-induced osteonecrosis of the femoral head

摘要:

激素诱导性股骨头坏死（steroid-induced osteonecrosis of the femoral head, SONFH）病理特征为骨细胞缺血、坏死、骨小梁断裂，股骨头塌陷。终末期 SONFH 临床表现为疼痛、关节功能障碍，是一类可致残的难治性骨科疾病。此病的发病机制错综复杂，常表现为多路径相互联合或交叉作用导致。本文对 SONFH 的发病机制及相关信号通路的研究进展进行综述，为进一步认识 SONFH 的发病机制及其防治研究提供帮助。

Abstract:

Steroid-induced osteonecrosis of the femoral head (SONFH) is a style of pathology characterized by osteocyte ischemia, necrosis and trabecular fracture and femoral head collapse. The end-stage SONFH with clinical manifestations of pain and joint dysfunction is a disabling and refractory orthopedic disease. This disorder has complex pathogenesis, often manifested by the combination or cross-action of multiple pathways. In this review, the pathogenesis and related signaling pathways of SONFH were reviewed in order to further understand the pathogenesis and prevention of SONFH.