Abstract:[Objective] To introduce the surgical technique and preliminary clinical results of computer aided design (CAD) assisted cervicothoracic hemivertebrae resection and deformity correction. [Methods] From January 2016 to December 2020, 14 patients with congenital cervicothoracic hemivertebra malformations were treated with CAD assisted cervicothoracic hemivertebra resection and deformity correction. Mimics software was used to perform orthopedic design and simulate the orthopedic process before surgery. Under neuroelectro-physiological monitoring system used during surgery to ensure the safety of surgical correction, pedicle screws were precisely inserted according to the preoperative design, half vertebra was removed, and the scoliotic deformity was corrected by pedicle screw-rod system. The brace was worn after operation to maintain the correction effect. [Results] All patients were successfully operated, with no serious vascular, nerve and organ injuries and other complications. A total of 140 pedicle screws were inserted, with an accuracy of 97.1%. Compared with those preoperatively, the cervicothoracic scoliotic angle [(53.9±17.9)°, (11.5±2.5)°, P＜0.001], the kyphotic angle [(27.8±9.8)°, (10.7±1.6)°, P＜0.001] significantly improved at the latest follow-up lasted for (35.5±13.2) months. In addition, the torticollis angle, T1 inclination and clavicular angle were significantly reduced postoperatively (P＜0.05). No loss of correction, pseudoarthrosis and loosening of internal fixation occurred in anyone of them during follow-up. [Conclusion] The CAD assisted cervicothoracic hemivertebra resection and deformity correction are safe and effective to insert pedicle screws and complete hemivertebra resection accurately, and improve surgical efficiency.