Abstract:[Objective] To present the preliminary results of periosteal stretching in the treatment of diabetic foot. [Methods] A retrospective study was conducted on 22 patients who received tibial periosteal stretching for diabetic foot in our hospital from April 2020 to March 2022. The clinical and laboratory results were evaluated. [Results] All patients were operated on successfully, with no serious complications such as neurovascular injury, and were followed up for an average of (8.7±1.2) months. The patients got foot wound healing in an average of (31.5±2.2) days, with the limb preservation rate of 100%. Compared with those preoperatively, the VAS score [(5.3±0.8), (3.1±0.7), (2.9±0.7), P＜0.001], ankle brachial index [(0.6± 0.1), (0.8±0.3), (1.0±0.4), P＜0.001], the foot skin temperature [(25.9±2.4)℃, (27.7±3.1)℃, (29.0+4.0)℃, P＜0.001], percutaneous oxygen partial pressure [(24.7±4.2) mmHg, (36.2±3.8) mmHg, (45.7±5.3) mmHg, P＜0.001], SemmesWeinstein monofilament test [(4.8±0.9) g, (5.4±0.8) g, (7.5±0.8) g, P＜0.001] improved significantly 23 days and 93 days postoperatively. In terms of blood test, the levels of vascular endothelial growth factor, basic fibroblast growth factor, epidermal cell growth factor, and plateletderived growth factor increased significantly 10 days or 24 days after surgery compared with those preoperatively (P＜0.05). [Conclusion] Periosteal stretching does significantly promote microvascular regeneration and vascular reconstruction in chronic refractory wounds of diabetic foot, and promote wound healing of affected limb.