p53蛋白在骨质疏松中作用的研究进展△

Research progress on role of p53 protein in osteoporosis

摘要:

骨质疏松症（osteoporosis, OP） 是一种中老年人易患的骨代谢性疾病，以骨密度减低和骨微结构破坏为特征，伴随着大量的骨丢失，极易导致身体各部位发生脆性骨折，造成沉重的家庭及社会负担。因此，对OP 基础理论研究及新药物开发具有重要的意义。随着OP 分子机制研究的不断深入，相关调控因子陆续被发现，p53 蛋白是细胞内重要的调控因子，调节着机体内各种细胞的增殖、分化、凋亡、自噬等多个生命过程。越来越多的证据表明，p53 的表达量高低对骨的功能及代谢有着重要的调节作用，或将成为治疗OP 等骨代谢疾病的新靶点。

Abstract:

Osteoporosis (OP) is a kind of bone metabolic disease usually happened in middle-aged and elderly, characterized by thereduction of bone mineral density and the destruction of bone microstructure. Accompanied by a large number of bone loss, it is easy to leadto fragility fractures in various parts of the body, causing heavy family and social burden. Therefore, it is of great significance to study thebasic theory of OP and develop new drugs. With the deepening of research on the molecular mechanism of OP, relevant regulatory factorshave been discovered one after another. p53 protein is an important intracellular regulatory factor, regulating the proliferation, differentia-tion, apoptosis, autophagy and other life processes of various cells in the body. The evidence is growing that p53 plays an important role inregulating the function and metabolism of bone and may become a new target for the treatment of bone metabolic diseases including OP.