Abstract:[Objective] To explore the significance of anchored Kirschner wire used as a guide in endoscopic lumbar interbody fusion (Endo-LIF) for lumbar degenerative diseases (LDD). [Methods] A retrospective study was done on 108 patients who received Endo-LIF for LDD in our hospital from January 2021 to January 2023. According to preoperative doctor-patient discussion, 53 patients had Endo-LIF performed in conventional manner with the visualizing trephine (the traditional group), while other 55 patients received Endo-LIF with the visualizing trephine following the guide by anchored Kirschner wire (the K-wire group). The perioperative, follow-up and imaging data of the two groups were compared. [Results] All patients in both groups successfully completed operation without serious complications. The K-wrie group proved significantly superior to the traditional group in terms of operative time [(108.1±5.5) min vs (122.4±6.5) min, P<0.001], intraoperative blood loss [(56.3±6.7) ml vs (71.5±10.2) ml, P<0.001], intraoperative fluoroscopy duration [(13.1±1.3) s vs (17.2±0.9) s, P<0.001], despite of the fact that no significant differences were noted in postoperative walking time and hospital stay between them (P>0.05).All patients in the two groups were followed up for (20.8±4.0) months, and there was no significant difference in time to regain full weight-bearing activities between the two groups (P>0.05). As time went on, lower back pain VAS, leg pain VAS and ODI scores significantly decreased (P<0.05), while JOA scores significantly increased in both groups (P<0.05), whereas which were not significantly different between the two cohorts at any time points accordingly. With respect of imaging, there were no significant changes in lumbar lordosis angle in both groups at the last follow-up compared with that preoperatively (P>0.05). At the last follow-up, there was no a significant difference in the Bridwell grade of interbody fusion between the two groups (P>0.05). [Conclusion] Endo-LIF following guide of anchored Kirschner wiredoes achieve good results in the treatment of LDD, which can not only improve the efficiency of intraoperative laminar fenestration, reduce intraoperative bleeding, but also reduce doctor and patient radiation.