警报素在椎间盘退变中作用的研究进展△

Research progress on the role of alarmins in intervertebral disc degeneration

摘要:

椎间盘退变 （intervertebral disc degeneration, IVDD） 是一类骨科常见的疾病，给社会经济和人体健康造成了巨大的负担。目前，椎间盘退变的治疗手段仅能缓解患者症状，无法阻止椎间盘退变的进程。炎症反应是椎间盘退变的重要原因之一。损伤相关分子模式（damage-associated molecular pattern, DAMP）是体内重要的一种免疫应答方式，警报素作为 DAMP 的配体，是一类在炎症反应中发挥重要功能的分子。警报素包括高迁移率族蛋白 B1（high mobility group box-1 protein, HMGB1）、热休克蛋白（heat shock protein, HSP）、S100 蛋白家族、白细胞介素-1α （interleukin-1α, IL-1α）和白细胞介素-33 （interleukin33, IL-33）等蛋白，在机体应对外界引起的炎症反应、免疫应答过程中起着重要的作用。本文以不同警报素在椎间盘退变的作用及机制进行综述，以期为后续研究提供参考。

Abstract:

Intervertebral disc degeneration (IVDD) is a prevalent orthopedic condition that imposes a significant burden on both the social economy and human health. Currently, treatments for IVDD can only relieve patients' symptoms but cannot stop the process of disc degeneration. Inflammation stands as one of the key contributors to intervertebral disc degeneration, while damage-associated molecular pattern (DAMP) represents an essential immune response mechanism in vivo. Alarmin, as a ligand of DAMP, is a class of molecules that play an important role in inflammatory response. Alarmins encompass high mobility group box- 1 protein (HMGB1), heat shock proteins (HSPs), S100 protein family, interleukin-1α (IL-1α), and interleukin-33 (IL-33). This review aims to explore the effects and mechanisms of different alarmins on intervertebral disc degeneration, providing valuable references for future studies.