应力诱导椎间盘退变的研究进展△

Advances in stress-induced intervertebral disc degeneration

摘要:

腰背痛是一种常见的脊柱退行性疾病，目前已经发展成为严重的社会问题。近期研究表明，椎间盘退变（interverte- bral disc degeneration, IDD）是导致腰背痛的首要原因，抑制 IDD 是防治腰背痛的重要靶点。导致 IDD 的原因包括老龄、遗传、 机械负荷、营养缺乏等。近年来，越来越多的研究报道了机械应力 （mechanical stress, MS） 导致的 IDD，MS 诱导 IDD 的分子机制复杂多变，包括调控凋亡、焦亡、铁死亡、衰老、自噬、氧化应激、内质网应激、炎性反应和 ECM 降解等，但其确切机制尚不明确。本文拟对 MS 诱导 IDD 的机制进行综述，为临床预防和治疗腰背痛提供理论参考。

Abstract:

Low back pain is a common degenerative disease of the spine that has developed to be a serious social problem. Recent studies have shown that intervertebral disc degeneration (IDD) is the primary cause of low back pain, whereas inhibiting IDD is an important target for preventing and treating LBP. Causes of IDD include ageing, genetics, mechanical stress, and nutritional deficiencies. In recent years, an increasing number of studies have reported IDD caused by mechanical stress (MS), but the exact mechanism is still unclear. This paper intends to review the mechanisms of MS-induced IDD and provide theoretical references for clinical prevention and treatment of low back pain.