间充质干细胞外泌体在肌腱损伤修复中的作用△

Effects of mesenchymal stem cell derived exosomes on repairing tendon injury

摘要:

肌腱损伤为临床常见病，由于肌腱自身愈合能力较差，自然愈合常形成瘢痕组织，无法达到功能性恢复，严重影响患者的运动功能及生活质量。现有治疗手段虽均已取得一定成效，但仍无法完全恢复损伤肌腱的原有结构及功能。近年来，间充质干细胞衍生的外泌体作为组织修复与再生领域的新兴手段虽已广泛应用，但针对间充质干细胞外泌体治疗肌腱损伤的研究较少，且具体机制并不完善。本文针对不同源性间充质干细胞外泌体对肌腱损伤修复作用的研究进展及其相关组织工程技术作一综述，为肌腱损伤的临床治疗及应用研究提供理论支持。

Abstract:

Tendon injury, a common clinical disease, usually has scar tissue formed in natural healing with improper functional recovery, which seriously affects the motor function and quality of life of patients due to the poor healing ability of tendon itself. Although the existing treatment methods have achieved some results, they still cannot completely restore the original structure and function of the injured tendon. In recent years, exosomes derived from mesenchymal stem cells have been widely used as a new means in the field of tissue repair and regeneration, however, there are few studies on the treatment of tendon injury by mesenchymal stem cell exosomes, and the specific mechanism is not fully understood. In this review, the research progresses of different mesenchymal stem cell derived exosomes on tendon injury repair and related tissue engineering techniques were reviewed, providing theoretical support for the clinical treatment and applied research of tendon injury.