前交叉韧带断裂关节腔内环境改变的研究进展△

Research progress on the intraarticular environment variation secondary to anterior cruciate ligament tear

摘要:

前交叉韧带（anterior cruciate ligament, ACL） 断裂多发于运动的人群，特别是年轻人，该韧带断裂后由于关节腔内环境以及关节力学的改变，导致膝关节疼痛、不稳定以及活动功能障碍等症状，给患者带来长期的负面影响。有许多研究表明，ACL 断裂后可引起滑膜炎症、软骨细胞损伤以及软骨基质的降解，最后导致创伤后骨关节炎（posttraumatic osteoarthritis,PTOA） 形成，其中引起关节腔内这些变化的原因可能与ACL 断裂后关节腔内环境改变有着密切的关系。本文主要从ACL 断裂后关节腔内环境的改变出发，分析术前术后关节腔内环境的改变对患者预后的影响，为ACL 断裂后形成PTOA 提供一个可靠的科学依据。

Abstract:

Anterior cruciate ligament (ACL) tear is more common in people who exercise, especially in young people. Due to thechange of intraarticular environment and joint mechanics, the rupture of this ligament can lead to symptoms such as knee pain, instabilityand mobility dysfunction, which will bring long-term negative effects to patients. It is worth noting that many studies have shown that ACLrupture can cause synovial inflammation, chondrocyte injury and cartilage matrix degradation, and finally lead to posttraumatic osteoarthri-tis (PTOA). The causes of these changes in the articular cavity may be closely related to the changes in the articular cavity environment af-ter ACL tear. Therefore, based on the changes in the intraarticular environment after ACL rupture, this paper mainly analyzes the influenceof the changes in the intraarticular environment before and after surgery on the prognosis of patients, and provides a reliable scientific basisfor the predicating PTOA after ACL rupture.