Abstract:[Objective] To evaluate the outcomes of the targeted nursing in perioperative period of pedicle screw fixation of ankylosing spondylitis (AS) spinal fractures. [Methods] From January 2020 to July 2023, 40 patients underwent posterior long-segment pedicle screwrod system fixation for AS spinal fractures, with targeted nursing measures implemented in the perioperative period. The negative emotion scores and quality of life scores were compared between the admission and discharge. [Results] All the 40 patients were successfully operated without serious complications. Compared with those at admission, the self-rating depression scale (SDS) [(60.2±5.7), (48.2±4.1), P＜ 0.001] and self-rating anxiety scale (SAS) [(58.1±5.8), (48.7±3.1), P＜0.001] significantly decreased, while the generic quality of life inventory-74, GQOLI-74, including physical function [(60.1±6.2), (85.2±8.1), P＜0.001], the psychological function [(62.8±7.2), (88.3±9.2), P＜ 0.001], the social function [(61.5±8.1), (90.6±8.2), P＜0.001] and material life state [(65.2±7.7), (88.3±8.2), P＜0.001] significantly increased at discharge. [Conclusion] Surgical fixation of spinal fracture of AS with special nursing intervention in perioperative period can alleviate negative emotions and improve quality of life.