Abstract:[Objective] To explore the clinical efficacy of ultrasound-guided closed reduction and percutaneous Kirschner wire fixation for calcaneal fractures in children. [Methods] A retrospective study was conducted on 100 children admitted into our hospital for calcaneal fractures from January 2020 to August 2022. All of them received closed prying reduction and percutaneous Kirschner wire fixation. According to preoperative doctor-patient communication, 55 cases had operation performed under ultrasound guidance (ultrasound group), while other 45 cases were under fluoroscopy (fluoroscopy group). The perioperative, follow-up and imaging data of the two groups were compared. [Results] The ultrasound group proved significantly superior to the fluoroscopy group in terms of operation time [(35.0±6.8) min vs (58.2±10.4) min, P<0.001] and imaging check time [(325.0±25.6) s vs (600.5±73.5) s, P<0.001], intraoperative fluoroscopy times [(2.7±0.8) times vs (10.2±2.8) times, P<0.001], walk time [(3.0±0.5) days vs (3.5±1.0) days, P=0.002] and hospital stay [(4.5±1.6) days vs (5.4±2.0) days, P=0.014]. Compared with those 1 month after surgery, the VAS score, AOFAS score, ankle dorsal-plantar flexion and inversion-eversion range of motions (ROMs) significantly improved in both groups at the last follow-up (P<0.05). One month after surgery, the VAS score in the ultrasound group was significantly better than that in the fluoroscopy group [(2.0±0.6) vs (2.3±0.7), P=0.023], whereas at other corresponding time points, there was no statistical significance in the above indexes between the two groups (P>0.05). Regarding imaging, the Bohler's angle, Gissane's angle and articular cartilage collapse height were significantly improved over time in both groups (P<0.05). The articular cartilage collapse height in the ultrasound group was significantly lower than that in the fluoroscopy group one month after surgery [(2.0±0.7) mm vs (2.5±0.6) mm, P<0.001], regardless of no statistically significant differences in other imaging indicators between the two groups at any corresponding time points (P>0.05). [Conclusion] Ultrasound-guided closed reduction and percutaneous Kirschner wire fixation has the advantages of shorter operation time, less radiation damage and less intraoperative bleeding over the fluoroscopy-guided counterpart for calcaneal fractures in children.