Abstract:[Objective] To compare the early outcomes of three kinds of anticoagulation treatment during perioperative period of total knee arthroplasty (TKA) in Tibetan patients. [Methods] From January 2021 to July 2021, 60 Tibetan patients who were undergoing TKA were included in this study and randomly divided into three groups by random number table method. Twenty patients in group A received aspirin 25 mg/day; 20 patients in group B received aspirin 100 mg/d; 20 patients in group C were treated with low molecular weight heparin calcium 0.4ml/d for anticoagulation. The results of clinical and color ultrasonography were evaluated. [Results] There were no significant differences in operation time, intraoperative blood loss and total blood loss among the three groups (P＞0.05). Compared with those 1 day postoperatively, VAS scores in the 3 groups were significantly decreased 3 days and 7 days postoperative (P＜0.05), the ROM was significantly increased (P＜0.05), with suprapatellar circumference remained unchanged (P＞0.05). At corresponding time points, there were no significant differences in VAS score, ROM and suprapatellar circumference among the three groups (P＞0.05). In terms of ultrasonography, there was no significant difference in the incidence of thrombus among the three groups (5% vs 5% vs 10%, P＞0.05). [Conclusion] In this study, there was no significant difference in the incidence of early postoperative thrombosis among the 25 mg aspirin, 100mg aspirin and low molecular weight heparin calcium after TKA.