Abstract:[Objective] To compare the clinical consequences of two blood managements during total hip arthroplasty (THA). [Methods] A total of 100 patients who underwent total hip replacement from January 2022 to December 2023 were included in this study. According to the preoperative doctor-patient communication, the patients were divided into multi-mode blood managements group (MMBM) and routine group, with 50 cases in each group. The clinical and laboratory documents of the two groups were compared. [Results] The MMBM group proved significantly superior to the routine group in terms of intraoperative blood loss [(282.0±39.3) ml vs (389.9±46.2) ml, P＜0.001], postoperative drainage volume [(114.5±18.5) ml vs (167.1±13.8) ml, P＜0.001], blood transfusion rate [case (%), 0 vs 6 (12), P=0.027], the drainage time [(35.5±5.1) hours vs (42.2±4.0) hours, P＜0.001] and postoperative hospital stay [(6.8±0.9) days vs (7.5±1.2) days, P=0.002]. Regarding laboratory test, the Hb and Hct significantly decreased in both groups after surgery compared with those before surgery (P＜0.05). Although there was no significant difference in Hb and Hct between the two groups before surgery (P＞0.05), the MMBM group had significantly higher-Hb and Hct than the routine group at all time points postoperatively (P＜0.05). [Conclusion] Multi-mode blood management does effectively reduce the perioperative blood loss and transfusion rate, shorten the postoperative hospitalization, and accelerate the recovery of patients.