Abstract:[Objective] To evaluate the complications of anteroinferior psoasoblique lateral interbody fusion (AIP-OLIF) under direct vision and exposure technique. [Methods] A retrospective study was conducted on 143 patients who received AIP-OLIF from April 2017 to August 2022. The complication and follow-up data were evaluated. [Results] All patients had operation performed successfully with operation time of (238.5±87.7) min, and intraoperative blood loss of (104.1±116.4) ml. Complications in total occurred in 39 patients, accounted for 19.6%. Intraoperative complications occurred in 12 cases (8.4%), including segmental artery injury in 2 cases, peritoneal injury in 2 cases, pleural injury in 2 cases, dural injury in 1 case and endplate injury in 5 cases. Early postoperative complications occurred in 12 patients (8.4%), including 6 patients had pain and numbness in the front of the left thigh on the 1st day after surgery, and 6 patients had mild iliopsoas muscle weakness and quadriceps muscle weakness after surgery, whereas all of them recovered to normal at 1-month follow-up. As time went during follow-up period lasted for (14.8±4.3) months, the VAS score and ODI score were significantly decreased (P<0.05), while JOA score was significantly increased (P<0.05). In 15 patients (10.5%), the fusion device subsidence was found in images one year after the operation, all of which remained grade 0 subsidence. [Conclusion] AIP-OLIF can still cause intraoperative and postoperative complications, which should be paid attention to.