Abstract:[Objective] To compare the clinical efficacy of arthroscopic knotless anchor versus cannulated screw for fixation of posteri-or cruciate ligament (PCL) tibial avulsion fractures. [Methods] A retrospective study was performed on 28 patients who received arthroscop-ic reduction and fixation of acute PCL tibial avulsion fractures in our hospital from October 2013 to October 2020. According to doctor-pa-tient communication, 14 patients had fractures fixed with knotless anchors, while the other 14 patients were with cannulated screws. Theperioperative, follow-up and imaging data were compared between the two groups. [Results] All patients were operated on smoothly withoutserious complications. There were no significant differences in operation time, incision length, blood loss, incision healing grade and hospi-tal stay between the two groups (P>0.05). The anchor groups proved significantly superior to the screw group in terms of intraoperative fluo-roscopy [(0) times vs (2.1±0.4) times, P<0.001] and postoperative analgesic use [(2.1±0.5) days vs (3.1±0.6) days, P<0.001], despite of thefact that the former spent significantly higher medical cost than the latter [(29 677.3±2 406.3) yuan vs (18 605.2± 953.7) yuan, P<0.001].There was no significant difference between the two groups in the time to regain full-weight bearing activity (P>0.05). Compared with those3 months after surgery, the VAS, IKDC and Lysholm scores, as well as ROM significantly improved in both groups at the last follow-up (P<0.05), which were not statistically significant between the two groups at any time points accordingly (P>0.05). Regarding to imaging, therewere no statistically significant differences in fracture reduction quality and fracture healing time between the two groups (P>0.05). At thelast follow-up, there was no significant imaging change of worsening knee degeneration in both groups. [Conclusion] Both knotless anchorand cannulated screw fixation do achieve good consequences for PCL tibial avulsion fractures. In contrast, the knotless anchor has higherpostoperative comfort but higher treatment costs.