滑膜间充质干细胞修复软骨损伤的研究进展△

Research progress on synovial mesenchymal stem cells to repair cartilage damage

摘要:

软骨是关节的重要结构，在关节腔内起润滑关节、缓冲压力的作用。软骨损伤会导致膝骨关节炎（knee osteoarthri-tis, KOA），严重影响患者的生活质量。目前临床用于治疗KOA 的手段并不能修复受损软骨。近年来，滑膜间充质干细胞（sy-novial mesenchymal stem cells, SMSCs） 以其在软骨损伤修复方面的独特优势，成为修复受损软骨的热点研究领域。本文对SMSCs 修复软骨损伤的机制及体内外研究进展进行综述，以期推动SMSCs 修复软骨损伤向临床转化。

Abstract:

Cartilage is an important structure of joint, and plays role in lubricating the joint and cushioning pressure within the jointcavity. Cartilage injury can lead to knee osteoarthritis (KOA), severely affecting patients' quality of life. Current clinical methods used totreat KOA cannot repair damaged cartilage. In recent years, synovial mesenchymal stem cells (SMSCs) have shown unique advantages in re-pairing cartilage injuries, making it a hot research field for cartilage repair. Therefore, this article provides a comprehensive review of themechanisms and research progress of SMSCs in repairing cartilage injuries, with the aim of promoting the clinical translation of SMSCs incartilage repair.