Abstract:[Objective] To investigate the early outcomes of diversified rehabilitation and nursing care on pain, quality of life and func-tional recovery in open reduction and internal fixation (ORIF) of ankle fractures. [Methods] From February 2023 to February 2024, 66 pa-tients who were undergoing ORIF for ankle fractures in our hospital were included in this study, and were randomly divided into two groupsby numerical table method. Among them, 33 patients were treated with conventional perioperative rehabilitation and nursing, while other 33patients received diversified perioperative nursing and rehabilitation, mainly with increasing active functional exercise in the early stage,and the external application of traditional Chinese medicine in the late stage. The documents regarding to early clinical conditions werecompared between the two groups. [Results] All patients in both groups were successfully operated on without serious complications. The di-versified group proved significantly superior to the conventional group in terms of postoperative ambulation time [(2.1±0.6) days vs (3.7±1.1)days, P＜0.001], hospital stay [(8.0±1.6) days vs (12.0±3.0) days, P＜0.001] and pain VAS score at discharge [(3.1±0.7) vs (5.5±1.4), P＜0.001], as well as WHOQOL-Brief scores, including physical health [(70.5±3.1) vs (60.1±3.7), P＜0.001], mental health [(1.1±4.2) vs (58.9±3.1), P＜0.001], social relations [(72.1±4.4) vs (60.2±4.1), P＜0.001] and the surrounding environment [(72.6±4.2) vs (60.7±3.7), P＜0.001].In addition, the diversified group was also regained full weight-bearing activities significantly earlier than the conventional group [(61.0±4.4) days vs (76.1±7.1) days, P＜0.001]. [Conclusion] The implementation of multiple rehabilitation and nursing intervention in periopera-tive period of ORIF of ankle fractures not only significantly reduces pain, but also benefit the recovery of ankle joint function and improvethe quality of life of the patients.