Abstract:[Objective] To evaluated clinical consequences of closed reduction and percutaneous Kirschner wire fixation of Jacob typeIII lateral humeral condylar fracture (LHCF) in children. [Method] A retrospective research was conducted on 37 children who had Jacobtype III LHCF fixed with Kirschner wires in our hospital from December 2020 to August 2022. Based on preoperative communication be-tween doctors and patients, 19 children received closed reduction and percutaneous Kirschner wire fixation (the CRPF group), while other18 patients were treated by open reduction and internal fixation with Kirschner wire (the ORIF group). The documents regarding to perioper-ative period, follow-up, and images were compared between the two groups. [Result] All patients in both groups had operation performedsuccessfully without any serious complications, such as neurological or vascular damage during the operation. The CRPF group proved sig-nificantly superior to the ORIF group in terms of intraoperative bleeding [(11.3±0.4) ml vs (67.9±2.0) ml, P<0.001], operation time [(39.2±6.1) min vs (68.4±7.7) min, P<0.001], and hospital stay [(6.3±0.1) days vs (13.5±0.2) days, P<0.001], while the CRPF group consumed sig-nificantly greater number of intraoperative fluoroscopy than the ORIF group [(8.6±1.2) times vs (4.0±1.1) times, P<0.001]. There was no sta-tistically significant difference in time of postoperative external fixation time and incision healing grade between the two groups (P>0.05).All patients in both groups were followed up for 9~15 months, with an average of (12.3±0.3) months. There were no statistically significantdifferences in time to regain full weight-bearing activity and Flynn scale at the latest follow-up between the two groups of patients (P>0.05). The VAS score and MEPS score significantly improved in both groups over time (P<0.05). The CRPF group was significantly betterthan the ORIF group in VAS one day after surgery [(4.6±1.0) vs (6.9±0.9), P<0.001], despite of the fact that there was no statistically signifi-cant difference in VAS score and MEPS score between the two groups at the remaining time points (P>0.05). As for radiology, there was nosignificant difference in fracture reduction quality, fracture healing time, carrying angle and SCA between the two groups (P>0.05), and allchildren in both groups had fractures healed without any loosening or fracture of internal fixation at the latest follow-up. [Conclusion]Closed reduction and percutaneous Kirschner wire fixation of Jacob type III lateral humeral condylar fracture in children has the advantag-es of shortening surgical time, minimizing bleeding, no need for incision, relieveing postoperative pain, and is beneficial for early recoveryof the fracture in children.