Abstract:[Objective] To compare the clinical efficacy of folded repair (FR) and direct repair (DR) of the medial patellofemoral liga-ments (MPFL) with suture anchors for acute patellar dislocation with patellar side injury. [Methods] A retrospective study was conductedon 34 patients who received MPFL repair with suture anchors for acute patellar dislocation from October 2015 to May 202. According to thedoctor-patient discussion, 18 patients underwent FR, while the remaining 16 patients underwent DR. The documents regarding to perioper-ative period, follow-up and imaging were compared between the two groups. [Results] All the patients in both groups got operation per-formed successfully with no statistically significant differences in terms of operation time, incision length, intraoperative blood loss, postop-erative walking time and hospital stay between the two groups (P>0.05). All of them were followed up for an average of (4.3±1.1) years, andthere was no significant difference in time to resume full weight-bearing activity between the two groups (P>0.05). The VAS score for anteri-or knee pain, IKDC and Kujala scores, as well as knee flexion extension range of motion (ROM) were significantly improved in both groupsat the last follow-up compared with those preoperatively (P<0.05), whereas which were not of statistically significant differences betweenthe two groups at any time points accordingly (P>0.05). During follow-up, no re-dislocation occurred in anyone of the FR group, whereas 2patients (2/16) of re-dislocation happened in the DR group. Radiographically, the patellar tilt (PT) and patellar shift (PS) were significantlyreduced in both groups at the last follow-up compared with pre-operation (P<0.05), however, there were no statistically significant differ-ences in the abovementioned imaging measurements between the two groups in any matching time points (P>0.05). [Conclusion] The clini-cal outcomes of the two kinds of suture-anchor repair is satisfactory and comparable for acute patellar dislocation due to patellar side inju-ry. However, the folded repair might take a advantage of preventing patellar re-dislocation over the direct repair.