Abstract:[Objective] To compare the clinical efficacy of Multiloc intramedullary nail fixation of proximal humerus fractures (PHF)with or without medial column supporting reconstruction in the elderly. [Methods] A retrospective study was done on 84 elderly patientswho receive Multiloc intramedullary nail fixation for PHF in our hospital from January 2020 to August 2022. According to doctor-patientcommunication, 44 patients underwent the fixation with medial column supporting reconstruction (the reconstruction group), while the other40 patients underwent Multiloc intramedullary nail fixation alone (the non-reconstruction group). The perioperative period, follow-up andimaging parameters were compared between the two groups. [Results] Although the reconstruction group consumed significantly longer op-erative time than the non-reconstruction group [(90.7±9.0) min vs (85.0±8.5) min, P=0.004], the former was significantly superior to the lat-ter in terms of time to regain initiative activity [(5.5±1.3) days vs (6.4±1.5) days, P=0.004] and the hospital stay [(7.5±1.4) days vs (8.6±2.0)days, P=0.004]. There were no significant differences in the total incision length, intraoperative blood loss, postoperative drainage volumeand incision healing grade between the two groups (P>0.05). The mean follow-up time was of (16.0±2.5) months, while the reconstructiongroup resumed full weight-bearing activities significantly earlier than the non-reconstructed group [(82.6±9.8) days vs (115.0±17.4) days,P<0.001]. The VAS, ASES, Constant-Murley scores were significantly improved in both groups over time (P<0.05), in which the reconstruc-tion group was significantly better than the non-reconstruction group at all time point accordingly (P<0.05). In addition, the reconstructiongroup was also significantly better than the non-reconstruction group in forward flexion uplifting and abduction uplifting range of motions(ROMs) at 3 months after surgery (P<0.05), but which became not significant different between the two groups at 12 months after surgery(P>0.05). Regarding imaging, there were no significant differences in fracture reduction quality, fracture healing time and humeral neck-shaft angle (HNSA) immediately after surgery or at the last follow-up between the two groups (P>0.05). [Conclusion] Medial column supporting reconstruction combined with Multiloc intramedullary nail fixation is safe and effective in the treatment of elderly PHF, which isconducive to functional recovery and improvement of shoulder joint motion.