3D打印组织工程半月板的研究现状△

Research status of 3D printing tissue engineering meniscus

摘要:

半月板撕裂在骨科疾病中越来越常见，由于半月板的组织特殊性，通常通过保守治疗或者手术治疗撕裂的半月板来避免发展为骨关节炎。因为半月板缺乏血液供应，且具有不可再生性，所以无论是外伤性或者退行性病变，半月板切除后都会导致后期骨关节炎的发生。随着3D 打印技术的兴起，给半月板修复带来了希望。当然，3D 打印需要高精密的仪器和性能优良的3D 打印墨水。本综述对目前用于生物打印的不同生物墨水（包括细菌纤维素） 进行了深入的讨论，并概述了其进一步发展的前景。

Abstract:

Meniscal tears are becoming increasingly common in orthopedic field. Due to its histological specificity, the torn meniscus isusually treated conservatively or surgically to prevent the development of osteoarthritis. Because the meniscus lacks blood supply and is nonrenewable,whether it is traumatic or degenerative tear the meniscectomy will lead to the occurrence of later osteoarthritis. With the rise of3D printing technology, it has brought hope to meniscus repair. Of course, 3D printing requires highly sophisticated instruments and thepreparation of 3D printing inks with excellent properties. This review provides an in-depth discussion of the different bioinks currently usedfor bioprinting and outlines prospects for their further development. In addition, bacterial cellulose, which was found to be a 3D printing inkwith good performance, is introduced in this paper.