Abstract:[Objective] To evaluate the clinical outcome of arthroscopic debridement combined with distal femoral osteotomy for kneeosteoarthritis. [Methods] A retrospective study was done on 56 patients who received abovesaid treatment for knee osteoarthritis in our de-partment from February 2019 to February 2022. The clinical and imaging data were evaluated. [Results] All patients had operation per-formed successfully, with no serious complications, such as neurovascular injury, and followed up for a mean of (21.6±2.7) months. Com-pared with the preoperative results, VAS score significantly reduced [(6.2±0.9), (0.5±0.5), P=0.003], KSS score [(36.4±8.1), (81.4±1.1), P<0.001], knee ROM [(130.1±0.3)°, (139.3±0.4)°, P<0.001] increased significantly at the last follow-up. In term of imaging, the patients hadfemorotibial angle (FTA) [(80.6±0.4)°, (87.4±0.3)°, P=0.002], mechanical lateral distal femoral angle (mLDFA) [(167.7±2.8)°, (176.8±0.2)°,P<0.001] significantly increased at the last follow-up compared with those preoperatively, with no complications, such as bone nonunion orplate fracture found in anyone of them. [Conclusion] Arthroscopic debridement combined with distal femoral osteotomy for the treatment ofknee osteoarthritis can relive the symptoms and delay the progression of osteoarthritis.